Superbe etude par Catalini et al, qui analyse toutes les etudes publies jusqu'en 2011 sur les problematiques des hanches metal sur metal.
LIEN: http://het.sagepub.com/content/31/5/421
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Abstract
Neurotoxicity of cobalt
- 1Department of Experimental and Applied Medicine, Section of Occupational Health and Industrial Hygiene, University of Brescia, Italy
- 2Department of Medical and Surgical Sciences, Unit of Neurology, University of Brescia, Italy
- Simona Catalani, Department of Experimental and Applied Medicine, Section of Occupational Health and Industrial Hygiene, University of Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy Email: catalani@med.unibs.it
Lire tout l'article - conclusion interessantes:
Abstract
Cobalt exerts well-known and documented
toxic effects on the thyroid, heart and the haematopoietic system, in
addition to
the occupational lung disease, allergic
manifestations and a probably carcinogenic action. Cobalt neurotoxicity
is reported
in isolated cases, and it has never been
systematically treated. Bilateral optic atrophy and retinopathy,
bilateral nerve
deafness and sensory-motor polyneuropathy have been
described long ago as a result of chronic occupational exposure to
cobal
powder or during long-term treatment of anaemia
with cobalt chloride. Recently, some patients with high levels of cobalt
released
from metal prosthesis have been referred as
presenting with tinnitus, deafness, vertigo, visual changes, optic
atrophy, tremor
and peripheral neuropathy. The aim of this work is
to group these cases and to identify a possible mechanism of cobalt
neurotoxicity,
focusing on hypothetic individual susceptibility
such as altered metal-binding proteins, altered transport processes in
target
cells or polymorphic variation of genetic
background.
